RIPK3 antibody (AA 1-120)

Catalog No. ABIN7167479

This Rabbit Polyclonal antibody specifically detects RIPK3 in IHC and ELISA. It exhibits reactivity toward Human.

Quick Overview for RIPK3 antibody (AA 1-120) (ABIN7167479)

Target: RIPK3 (Receptor-Interacting serine-threonine Kinase 3 (RIPK3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RIPK3 antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA

Product Details anti-RIPK3 Antibody

Binding Specificity: AA 1-120

Purpose: RIPK3 Antibody

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Receptor-interacting serine/threonine-protein kinase 3 protein (1-120AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for RIPK3

Target: RIPK3 (Receptor-Interacting serine-threonine Kinase 3 (RIPK3))

Alternative Name: RIPK3

Background:

Background: Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production.

Aliases: Receptor interacting protein 3 antibody, Receptor interacting serine threonine kinase 3 antibody, Receptor interacting serine/threonine protein kinase 3 antibody, Receptor-interacting protein 3 antibody, Receptor-interacting serine/threonine-protein kinase 3 antibody, RIP 3 antibody, RIP like protein kinase 3 antibody, RIP-3 antibody, RIP-like protein kinase 3 antibody, RIPK 3 antibody, RIPK3 antibody, RIPK3_HUMAN antibody

UniProt: Q9Y572

Pathways: Activation of Innate immune Response, Toll-Like Receptors Cascades